Man paralyzed in biking accident regains walking ability in peptide drug trial

and Experimental drugs It can help improve movement for patients with spinal cord injuries.

NVG-291 has been tested by injection peptide, in Stage 2 experience With qualified patients – some notice great results.

Larry Williams, a participant in the trial in Philadelphia, Pennsylvania, with Fox News Digital that he managed to walk again after an accident that caused paralysis.

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Williams, 58, was running on mountain riding on a small trail when he hit a tree. Although he was wearing a helmet, he was “immediately broken” from C4 vertebrates to C6 (specific bones in the cervical spine).

subject Spine surgeryBut he was paralyzed for two weeks until his body began to “wake up” and restore some movement after starting treatment.

Larry Williams from Philadelphia (in the photo) survived the paralysis of the mountain bicycle riding it. (Larry Williams)

Williams managed to walk “a little” with the help of pedestrians, but he is still suffering from complications with moving in areas such as his hands. He also lost 40 pounds after the accident.

After some research, discovered the NVG-291 experience and was considered an applicable candidate, as he told Fox News Digital.

For three months, starting in April 2024, Williams received daily injection of the drug, followed by one hour of Physical therapyWhich included hand and walking exercises with a flat on a flat path or a walking device.

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Williams also underwent blood tests and electrical physiological tests to measure the electrical activity of his nerves and muscles, as well as physical tests once a month.

At the end of the trial, Williams stated that he was able to walk 10 meters (32.8 feet), balanced with pedestrians, in 15 seconds, with an improvement over 45 seconds.

Although he has not received the medicine since July 2024, Williams continues to see Physical improvements After more than a year.

Larry Williams joined the NVG-291 experience as a patient with spinal cord injury in April 2024. (Larry Williams; Istock)

“I’m not really really hard. I am not at treatment,” Fox News Digital said. “But just a few days ago, I stood up and tried to deal with freedom and balance and raise one foot from the ground. I managed to do this for 30 seconds.”

“I didn’t do this. I cannot explain how that happened,” he added. “There are small improvements that are still happening.”

Williams said he tried the same maneuver six months ago and could not put his foot from the ground for three seconds.

“There are small improvements that are still happening.”

Since the experiment, Williams have continued to improve his ability to walk, and he can even swim rolls in the pool.

“I have contacted other people with the same injury like me, and many of them seem, after years and years of treatment, I reached what I am,” he said. “It seems that this type of shortcut has obtained an abbreviation … I like to reach the life that I had before, and to be completely independent.”

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After taking the experimental medicine, Williams said he managed to perform the physical tasks “easily and quickly.”

“It seems that the movement is in my legs a little smoother and less restricted over time,” he said. “I will not give up. I will continue to pay and try.”

How does the medicine work

In a separate interview with Fox News Digital, the main researcher, Dr. Monica Perez, Scientific President of Shirley Ryan, in Chicago and a professor of natural medicine and rehabilitation at North Western University, said that the drug was first tested on animals, which showed an improved kinetic function (movement).

Then the researchers conducted a random clinical trial in humans, where half of the participants received NVG-291, which contains an improvement repair molecule The function of the nervous system.

NVG-291 is the peptide drug that contains a repair molecule to improve the function of the nervous system. (Istock)

The drug is peptide, which is a small protein that works like a road barrier remover. After injuring the spinal cord, the body sends signals that tell the nerve fibers to stop growth. This medicine prevents these signals, so the nerves have a better chance of reproduction.

“This peptide can prevent those inhibited signals,” Ryan said. “There is little evidence in animals that can already enhance the growth of neurons.”

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Although the GLP-1 receptors are famous for Weight loss The treatment of diabetes is peptide, and Perez said that the treatment of spinal cord injury works differently.

She said: “It has a specific mechanism, and is more associated with repair, to try to enhance the growth of neurons that are affected by the infection of the central nervous system.”

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Spinal cord injuries are usually taken with cell treatments, such as Stem cells Perez referred to the bone marrow meat cells.

She added that this peptide approach, in contrast to that, “easy management”, could achieve “a similar goal”, which is “very safe”.

The researchers noticed “electrical physiology changes” in the group that received the experimental drug. (Istock)

Perez said more research is necessary to determine the time when the effects of this drug will continue.

She said: “We have noticed strong changes in physiology in the group that received the drug compared to the place of imaginary medicine, but we have no follow -up measurements.” “There is no way for us to understand the true period of these treatments.”

Due to the lack of accredited treatment from the FDA for spinal cord injuries, Perez said that the participants in this research are “very dedicated” The advancement of this science.

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While every patient may interact differently, Williams said he will recommend this treatment for other people with spinal cord injuries.

“It can really change things for people with injuries like me,” he said. “I just pray because everyone there is able to get a chance to restore their lives.”